POEMS syndrome with increased vascular endothelial growth factor(VEGF).
نویسندگان
چکیده
منابع مشابه
Monitoring of Vascular Endothelial Growth Factor in POEMS Syndrome
POEMS syndrome is a clinical unit with a very heterogenous clinical behavior. Its diagnostics as well as monitoring are not easy and depend on clinician ́s experience. We present three case reports of patients with POEMS syndrome with different clinical manifestation and course of the disease. Our presentation demonstrates the benefit of the use of biochemical parameter VEGF (vascular endothelia...
متن کاملVascular endothelial growth factor promoted endothelial progenitor cell mobilization into the peripheral blood of a patient with POEMS syndrome.
We assessed the percentage of endothelial progenitor cells (EPCs) in the peripheral blood of a patient with POEMS with elevated VEGF plasma levels. High VEGF plasma levels were associated with increased EPC concentration and treatment with an anti-VEGF antibody induced a consensual decrease of both parameters. In vitro cultures of the patient BM cells suggested that the stromal compartment coul...
متن کاملVascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: retrospective cohort study
OBJECTIVE POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) syndrome is a rare multisystem disease characterised by plasma cell dyscrasia and overproduction of vascular endothelial growth factor (VEGF). VEGF is assumed to be useful in monitoring disease activity, because VEGF levels usually decrease after treatment. However, there is no study to investigate whethe...
متن کاملOptic Disc Edema Responding to Localized Anti-vascular Endothelial Growth Factor Treatment in a Patient with POEMS Syndrome
Dear Editor, Although various underlying conditions such as increased intracranial pressure, inflammation, ischemia, or compression can induce optic disc edema (ODE), all forms of disc swelling ultimately result from blockage of axo-plasmic transport [1]. In contrast to these types of ODE, which can generally be managed by systemic treatment of the underlying etiology, we describe a case of ODE...
متن کاملThe utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS syndrome.
The POEMS syndrome is associated with elevated vascular endothelial growth factor (VEGF) levels. Several studies have compared serum VEGF levels between POEMS patients and other disease entities showing higher serum VEGF in POEMS syndrome; however, it is unknown whether serum levels are reliable and reproducible given variable platelet release of VEGF. We therefore compared plasma levels of VEG...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2002
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.91.752